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Chong, Anita S.

One or more keywords matched the following properties of Chong, Anita S.

Property	Value
overview	My lab has had a long-standing interest in understanding the basis of immunological tolerance and humoral immunity following allogeneic transplantation. We have been collaborating extensively with Dr. Marisa Alegre in studying how infections prevent the induction of transplantation tolerance or destabilize established tolerance, and understanding the fundamental mechanisms of robust transplantation tolerance. We recently have developed new approaches to track a defined population of endogenous allospecific T (CD4+effectors (Th1 and Tfh), CD4+Tregs and CD8 effector) and B cells (Class I and Class II reactive), and are now asking how each of these subsets of cells behave under conditions of rejection, memory/sensitization and tolerance, with the goal of identifying new biomarkers of tolerance and rejection. We also actively investigating the behavior of memory alloreactive B cells in the setting of transplantation, and in identifying how these cells differ from naïve B cells, with the goal of identifying immunosuppressive and tolerance inducing strategies to control this clinically important subset of cells. We are conducting these studies in experimental rodent models, and also testing our findings in humans. These studies are performed in collaboration with Dr. Roger Sciammas at UCDavis, and the clinical transplant faculty at the University of Chicago and Ohio State University. In addition, we have stretched our research into the prevention of infections through vaccination, with the long-term goal of using this strategy as an indirect but cost-effective means of stabilizing tolerance. Towards this goal, my lab has been collaborating with Dr. Chris Montgomery, a physician scientist in the Department of Pediatrics, to identify sub-unit vaccine candidates and to investigate the immunobiology of protection from Staphylococcus aureus skin infections. My lab also has a strong program of collaborative research with Dr. Joel Collier, a bioengineer at Duke University, to develop of nanoparticulate adjuvant-free vaccines that can elicit protective immune responses with minimal inflammation. Such a vaccine that elicits minimal inflammation may be ideal for tolerant patients, as we now appreciate that inflammation can destabilize established tolerance.

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overview

My lab has had a long-standing interest in understanding the basis of immunological tolerance and humoral immunity following allogeneic transplantation. We have been collaborating extensively with Dr. Marisa Alegre in studying how infections prevent the induction of transplantation tolerance or destabilize established tolerance, and understanding the fundamental mechanisms of robust transplantation tolerance. We recently have developed new approaches to track a defined population of endogenous allospecific T (CD4+effectors (Th1 and Tfh), CD4+Tregs and CD8 effector) and B cells (Class I and Class II reactive), and are now asking how each of these subsets of cells behave under conditions of rejection, memory/sensitization and tolerance, with the goal of identifying new biomarkers of tolerance and rejection. We also actively investigating the behavior of memory alloreactive B cells in the setting of transplantation, and in identifying how these cells differ from naïve B cells, with the goal of identifying immunosuppressive and tolerance inducing strategies to control this clinically important subset of cells. We are conducting these studies in experimental rodent models, and also testing our findings in humans. These studies are performed in collaboration with Dr. Roger Sciammas at UCDavis, and the clinical transplant faculty at the University of Chicago and Ohio State University. In addition, we have stretched our research into the prevention of infections through vaccination, with the long-term goal of using this strategy as an indirect but cost-effective means of stabilizing tolerance. Towards this goal, my lab has been collaborating with Dr. Chris Montgomery, a physician scientist in the Department of Pediatrics, to identify sub-unit vaccine candidates and to investigate the immunobiology of protection from Staphylococcus aureus skin infections. My lab also has a strong program of collaborative research with Dr. Joel Collier, a bioengineer at Duke University, to develop of nanoparticulate adjuvant-free vaccines that can elicit protective immune responses with minimal inflammation. Such a vaccine that elicits minimal inflammation may be ideal for tolerant patients, as we now appreciate that inflammation can destabilize established tolerance.

One or more keywords matched the following items that are connected to Chong, Anita S.

Item Type	Name
Concept	Transplantation Tolerance
Academic Article	Intact active bone transplantation synergizes with anti-CD40 ligand therapy to induce B cell tolerance.
Academic Article	Allograft tolerance induced by intact active bone co-transplantation and anti-CD40L monoclonal antibody therapy.
Academic Article	The multiple facets of toll-like receptors in transplantation biology.
Academic Article	Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article	Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming.
Academic Article	Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article	Expression of complement regulatory proteins in accommodated xenografts induced by anti-alpha-Gal IgG1 in a rat-to-mouse model.
Academic Article	Matchmaking the B-cell signature of tolerance to regulatory B cells.
Academic Article	Making a B-line for transplantation tolerance.
Academic Article	Experimental models of B cell tolerance in transplantation.
Academic Article	"Tip-toeing" to an assay for transplantation tolerance?
Academic Article	TLR engagement prevents transplantation tolerance.
Academic Article	Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article	Long-term control of alloreactive B cell responses by the suppression of T cell help.
Academic Article	Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article	IFN-gamma production is specifically regulated by IL-10 in mice made tolerant with anti-CD40 ligand antibody and intact active bone.
Academic Article	Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article	Transplantation tolerance and its outcome during infections and inflammation.
Academic Article	Microbes and allogeneic transplantation.
Academic Article	The influence of the microbiota on the immune response to transplantation.
Academic Article	Memory B cells in transplantation.
Academic Article	Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article	Transplantation tolerance after allograft rejection.
Academic Article	Erosion of Transplantation Tolerance After Infection.
Academic Article	Transplantation tolerance: don't forget about the B cells.
Academic Article	Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article	Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article	Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article	The pursuit of transplantation tolerance: new mechanistic insights.
Academic Article	Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article	B cells as antigen-presenting cells in transplantation rejection and tolerance.
Academic Article	The First ITS Meeting.
Academic Article	Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
Academic Article	Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.
Academic Article	Semiallogeneic Pregnancy: A Paradigm Change for T-cell Transplantation Tolerance.
Academic Article	Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article	Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article	Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Academic Article	Donor programmed cell death 1 ligand 1 is required for organ transplant tolerance in major histocompatibility complex-mismatched mixed chimeras although programmed cell death 1 ligand 1 and major histocompatibility complex class II are not required for inducing chimerism.
Academic Article	MHC Tetramers Specifically Identify High- and Low-avidity Donor-specific B Cells in Transplantation Tolerance and Rejection.
Academic Article	Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection.

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Transplantation Tolerance